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Issue 17, 2014
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A label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-triggered in situ catalysis of split DNAzyme

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Abstract

A novel label-free tailed hairpin-shaped activatable aptamer probe (THAAP) was developed by rationally integrating an aptamer and a split G-quadruplex into one sequence. Based on target recognition-triggered in situ catalysis of split DNAzyme, the THAAP strategy achieved a simple, fast, washing-free, specific and quantitative colorimetric assay of human leukemic CCRF-CEM cells.

Graphical abstract: A label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-triggered in situ catalysis of split DNAzyme

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Article information


Submitted
27 Mar 2014
Accepted
19 Jun 2014
First published
20 Jun 2014

Analyst, 2014,139, 4181-4184
Article type
Communication
Author version available

A label-free activatable aptamer probe for colorimetric detection of cancer cells based on binding-triggered in situ catalysis of split DNAzyme

H. Shi, D. Li, F. Xu, X. He, K. Wang, X. Ye, J. Tang and C. He, Analyst, 2014, 139, 4181
DOI: 10.1039/C4AN00561A

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