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Issue 11, 2014
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Touch spray mass spectrometry for in situ analysis of complex samples

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Abstract

Touch spray, a spray-based ambient in situ ionization method, uses a small probe, e.g. a teasing needle to pick up sample and the application of voltage and solvent to cause field-induced droplet emission. Compounds extracted from the microsample are incorporated into the sprayed micro droplets. Performance tests include disease state of tissue, microorganism identification, and therapeutic drug quantitation. Chemical derivatization is performed simultaneously with ionization.

Graphical abstract: Touch spray mass spectrometry for in situ analysis of complex samples

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Supplementary files

Article information


Submitted
25 Mar 2014
Accepted
09 Apr 2014
First published
23 Apr 2014

Analyst, 2014,139, 2714-2720
Article type
Paper
Author version available

Touch spray mass spectrometry for in situ analysis of complex samples

K. S. Kerian, A. K. Jarmusch and R. G. Cooks, Analyst, 2014, 139, 2714
DOI: 10.1039/C4AN00548A

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