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Issue 13, 2014
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Microfluidic-SERS devices for one shot limit-of-detection

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Microfluidic sensing platforms facilitate parallel, low sample volume detection using various optical signal transduction mechanisms. Herein, we introduce a simple mixing microfluidic device, enabling serial dilution of introduced analyte solution that terminates in five discrete sensing elements. We demonstrate the utility of this device with on-chip fluorescence and surface-enhanced Raman scattering (SERS) detection of analytes, and we demonstrate device use both when combined with a traditional inflexible SERS substrate and with SERS-active nanoparticles that are directly incorporated into microfluidic channels to create a flexible SERS platform. The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment.

Graphical abstract: Microfluidic-SERS devices for one shot limit-of-detection

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Article information

20 Feb 2014
05 Apr 2014
First published
07 Apr 2014

Analyst, 2014,139, 3227-3234
Article type

Microfluidic-SERS devices for one shot limit-of-detection

D. Kim, A. R. Campos, A. Datt, Z. Gao, M. Rycenga, N. D. Burrows, N. G. Greeneltch, C. A. Mirkin, C. J. Murphy, R. P. Van Duyne and C. L. Haynes, Analyst, 2014, 139, 3227
DOI: 10.1039/C4AN00357H

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