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Issue 5, 2014
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A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

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Abstract

The integration of ultrasound (US)-assisted sample processing on-chip in a lab-on-a-valve (LOV) format for automated high-throughput shotgun proteomic assays is herein presented for the first time. The proof of concept of this system was demonstrated with the analysis of three proteins and sera from patients with lymphoma or myeloma.

Graphical abstract: A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

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Article information


Submitted
23 Nov 2013
Accepted
03 Jan 2014
First published
20 Jan 2014

Analyst, 2014,139, 992-995
Article type
Communication
Author version available

A mesofluidic platform integrating on-chip probe ultrasonication for multiple sample pretreatment involving denaturation, reduction, and digestion in protein identification assays by mass spectrometry

J. D. Nunes-Miranda, C. Núñez, H. M. Santos, G. Vale, M. Reboiro-Jato, F. Fdez-Riverola, C. Lodeiro, M. Miró and J. L. Capelo, Analyst, 2014, 139, 992
DOI: 10.1039/C3AN02178E

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