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Issue 1, 2014
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Adenosine capped QDs based fluorescent sensor for detection of dopamine with high selectivity and sensitivity

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Abstract

Facile detection of dopamine (DA) in biological samples for diagnostics remains a challenge. This paper reported an effective fluorescent sensor based on adenosine capped CdSe/ZnS quantum dots (A-QDs) for highly sensitive detection of DA in human urine samples. In this assay, adenosine serves as a capping ligand or stabilizer for QDs to render high-quality QDs dispersed in water, and as a receptor for DA to attach DA onto the surface of A-QDs. DA molecules can bind to A-QDs via non-covalent bonding, leading to the fluorescence quenching of A-QDs due to electron transfer. The A-QDs based fluorescence probe showed a limit of detection (LOD) of ca. 29.3 nM for DA detection. This facile method exhibited high selectivity and anti-interference in the presence of amino acid, ascorbic acid (AA), uric acid (UA) and glucide with 100-fold higher concentration in PBS solution. Furthermore, it was also successfully used in the detection of DA in the human urine samples with quantitative recoveries (94.80–103.40%).

Graphical abstract: Adenosine capped QDs based fluorescent sensor for detection of dopamine with high selectivity and sensitivity

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Supplementary files

Article information


Submitted
22 Aug 2013
Accepted
27 Sep 2013
First published
30 Sep 2013

Analyst, 2014,139, 93-98
Article type
Paper

Adenosine capped QDs based fluorescent sensor for detection of dopamine with high selectivity and sensitivity

Q. Mu, H. Xu, Y. Li, S. Ma and X. Zhong, Analyst, 2014, 139, 93
DOI: 10.1039/C3AN01592K

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