Assessing DNA damage from enzyme-oxidized single-walled carbon nanotubes

Shenmin Pan; Naimish P. Sardesai; Hongyun Liu; Dandan Li; James F. Rusling

doi:10.1039/C3TX50022E

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Assessing DNA damage from enzyme-oxidized single-walled carbon nanotubes†

Shenmin Pan,^a Naimish P. Sardesai,^a Hongyun Liu,^b Dandan Li^a and James F. Rusling*^acd

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Connecticut, USA
E-mail: james.rusling@uconn.edu

^b Department of Chemistry, Beijing Normal University, China

^c Department of Cell Biology, University of Connecticut Health Center, USA

^d Institute of Materials Science, University of Connecticut, USA

Abstract

Peroxidase enzyme digests of oxidized single-wall carbon nanotubes (SWCNTs) were shown to damage DNA in potentially genotoxic reactions for the first time using an electro-optical array with and without metabolic activation.