*
Corresponding authors
a
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, The University of Liverpool, Sherrington Building, Ashton St., Liverpool, UK
E-mail:
dom@liv.ac.uk
Fax: +44 (0)151 794 5540
Tel: +44 (0)151 794 5791
b
Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK
c
Department of Chemical Engineering, University of Bath, Claverton Down, Bath, UK
d
Department of Mathematics and Statistics, University of Strathclyde, Livingstone Tower, 26 Richmond Street, Glasgow, UK
e
School of Mathematical Sciences, Loughborough University, Loughborough, UK
f
Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, UK
g
NC3Rs Gibbs Building, 215 Euston Road, London, UK