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Issue 47, 2013
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Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

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Abstract

Synthesis and ring opening polymerization of a new γ-substituted ε-caprolactone monomer, γ-(2-methoxyethoxy)-ε-caprolactone is reported. Amphiphilic diblock copolymers comprised of poly[γ-(2-methoxyethoxy)-ε-caprolactone] and thermosensitive poly{γ-2-[2-(2-methoxyethoxy)ethoxy]ethoxy-ε-caprolactone} as the hydrophobic and hydrophilic blocks, respectively, were prepared. The copolymers exhibited fully biodegradable backbones and highly tunable thermoresponsive behavior in the range of 31–43 °C. Additionally, the copolymers were shown to self-assemble in aqueous media above their respective critical micelle concentrations, on the order of 10−2 g L−1. Due to their thermosensitive, self-assembling, and biodegradable properties, these copolymers demonstrate potential for the use in polymeric micellar drug delivery systems.

Graphical abstract: Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

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Publication details

The article was received on 22 Oct 2013, accepted on 27 Oct 2013 and first published on 29 Oct 2013


Article type: Paper
DOI: 10.1039/C3TB21488E
J. Mater. Chem. B, 2013,1, 6532-6537

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    Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

    E. A. Rainbolt, K. E. Washington, M. C. Biewer and M. C. Stefan, J. Mater. Chem. B, 2013, 1, 6532
    DOI: 10.1039/C3TB21488E

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