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Issue 38, 2013
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Monodisperse collagen–gelatin beads as potential platforms for 3D cell culturing

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Abstract

A droplet-based microfluidics technique is used to produce monodisperse, 80 μm collagen–gelatin beads with tunable mechanical properties in the range of 1–10 kPa after photo-crosslinking. The gel beads are porous, mechanically robust and stable in buffer, but can be degraded enzymatically. Encapsulated fibroblast cells maintain 70% viability after one-week encapsulation and preliminary results show that the degree of spreading of cells in gels is correlated with the stiffness of the material.

Graphical abstract: Monodisperse collagen–gelatin beads as potential platforms for 3D cell culturing

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Supplementary files

Article information


Submitted
14 Jun 2013
Accepted
04 Aug 2013
First published
06 Aug 2013

J. Mater. Chem. B, 2013,1, 5128-5136
Article type
Paper

Monodisperse collagen–gelatin beads as potential platforms for 3D cell culturing

S. Ma, M. Natoli, X. Liu, M. P. Neubauer, F. M. Watt, A. Fery and W. T. S. Huck, J. Mater. Chem. B, 2013, 1, 5128
DOI: 10.1039/C3TB20851F

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