Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 32, 2013

Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

Author affiliations

Abstract

We engineered advanced biodegradable chitosan–alginate BSA-gel-capsules and demonstrated their applicability for the treatment of lung diseases. The pH-controlled loading and release of doxorubicin (DOX) was demonstrated. After treatment with DOX-loaded chitosan–alginate BSA-gel-capsules, effective cytotoxicity against B16F10 cells in vitro and higher efficacy of the pulmonary melanoma in vivo were revealed. In particular, the real-time biodistribution of DOX from DOX-loaded capsules was investigated for the first time, indicating the metabolism of capsules from the lung. These engineered capsules present new opportunities en route to the development of polyelectrolyte microcapsules for drug delivery.

Graphical abstract: Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

Supplementary files

Article information


Submitted
10 Mar 2013
Accepted
17 May 2013
First published
20 May 2013

J. Mater. Chem. B, 2013,1, 3906-3917
Article type
Paper

Biodegradable chitosan/alginate BSA-gel-capsules for pH-controlled loading and release of doxorubicin and treatment of pulmonary melanoma

H. Shen, H. Shi, M. Xie, K. Ma, B. Li, S. Shen, X. Wang and Y. Jin, J. Mater. Chem. B, 2013, 1, 3906 DOI: 10.1039/C3TB20330A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements