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Issue 30, 2013
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Double network hydrogels from polyzwitterions: high mechanical strength and excellent anti-biofouling properties

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Abstract

Polyzwitterionic materials, which have both cationic and anionic groups in the polymeric repeat unit, show excellent anti-biofouling properties and are drawing more attention in the biomedical field. In this study, we have successfully synthesized novel single network hydrogels and double network (DN) hydrogels from the zwitterionic monomer, N-(carboxymethyl)-N,N-dimethyl-2-(methacryloyloxy) ethanaminium, inner salt (CDME). The polyCDME (PCDME) single network hydrogel behaves like a hydrophilic neutral hydrogel and its properties are not sensitive to temperature, pH, or ionic strength over a wide range. DN hydrogels using the poly(2-acrylamido-2-methylpropanesulfonic) (PAMPS) as the first network and PCDME as the second network, having a Young's modulus of 0.2–0.9 MPa, possess excellent mechanical strength (fracture stress: 1.2–1.4 MPa, fracture strain: 2.2–6.0 mm/mm) and toughness (work of extension at fracture: 0.9–2.4 MJ m−3) depending on the composition ratio of PCDME to PAMPS. The strength and toughness of the optimized PAMPS/PCDME DN is comparable to the normal PAMPS/PAAm DN hydrogels that use poly(acrylamide) (PAAm) as the second network. By macrophage adhesion test, both the PCDME hydrogels and the PAMPS/PCDME DN hydrogels have shown excellent anti-biofouling properties. These results demonstrate that the PCDME-based DN hydrogels have high potential as a novel soft and wet biomaterial.

Graphical abstract: Double network hydrogels from polyzwitterions: high mechanical strength and excellent anti-biofouling properties

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Article information


Submitted
08 Mar 2013
Accepted
23 May 2013
First published
23 May 2013

J. Mater. Chem. B, 2013,1, 3685-3693
Article type
Paper

Double network hydrogels from polyzwitterions: high mechanical strength and excellent anti-biofouling properties

H. Yin, T. Akasaki, T. Lin Sun, T. Nakajima, T. Kurokawa, T. Nonoyama, T. Taira, Y. Saruwatari and J. Ping Gong, J. Mater. Chem. B, 2013, 1, 3685
DOI: 10.1039/C3TB20324G

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