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Issue 17, 2013
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Synthesis and drug delivery of novel amphiphilic block copolymers containing hydrophobic dehydroabietic moiety

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Abstract

Well-defined amphiphilic poly(ethylene glycol) and poly(dehydroabietic ethyl methacrylate) block copolymers (PEG-b-PDAEMA) were prepared by atom transfer radical polymerization. The methacrylate block contains a characteristic hydrophobic, biocompatible and economical dehydroabietic moiety. PEG-b-PDAEMA block copolymer micellar nanoparticles loaded with piperlongumine (PLGM) were successfully prepared by a nanoprecipitation method. In vitro and in vivo behaviors of these nanoparticles were thoroughly examined by a set of characterization techniques. Confocal laser scanning microscopy study revealed that these nanoparticles could be well taken up by cancer cells. In vivo near-infrared fluorescence imaging showed that the PLGM-loaded nanoparticles effectively targeted the tumor site by the enhanced permeability and retention (EPR) effect in H22 tumor-bearing mice. The in vivo antitumor examination found that PLGM-loaded nanoparticles exhibited superior efficacy in impeding the tumor growth compared to the commercially available Taxol® and free PLGM formulation. The changes in body weights and blood biochemical profiles were also compared to investigate the safety of PLGM and PEG-b-PDAEMA nanoparticle drug delivery system.

Graphical abstract: Synthesis and drug delivery of novel amphiphilic block copolymers containing hydrophobic dehydroabietic moiety

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Publication details

The article was received on 23 Jan 2013, accepted on 05 Mar 2013 and first published on 05 Mar 2013


Article type: Paper
DOI: 10.1039/C3TB20100G
Citation: J. Mater. Chem. B, 2013,1, 2324-2332
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    Synthesis and drug delivery of novel amphiphilic block copolymers containing hydrophobic dehydroabietic moiety

    J. Wang, K. Yao, C. Wang, C. Tang and X. Jiang, J. Mater. Chem. B, 2013, 1, 2324
    DOI: 10.1039/C3TB20100G

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