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Issue 20, 2013
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The preparation and drug delivery of a graphene–carbon nanotube–Fe3O4nanoparticle hybrid

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Abstract

We report a green and facile procedure of synthesizing a graphene nanosheetcarbon nanotubeiron oxide nanoparticle hybrid (GN–CNT–Fe3O4) as a promising platform for the loading and delivery of anticancer drugs. The obtained GN–CNT–Fe3O4 hybrid exhibited superparamagnetic properties with the saturation magnetization of 19.824 emu g−1. This hybrid nanostructure possesses a superior capability of binding the anticancer drug 5-fluorouracil (5-FU) with a high loading capacity of up to 0.27 mg mg−1 with a 5-FU concentration of 0.5 mg mL−1, and also possesses a pH-activated release profile. Moreover, cellular uptake studies show that the resulting GN–CNT–Fe3O4 hybrid can be internalized efficiently by HepG2 cells. In vitro cytotoxicity tests suggest that the obtained GN–CNT–Fe3O4 hybrid is nontoxic for Chang liver cells, even at the high concentration of 80 μg mL−1, however, the 5-FU-loaded GN–CNT–Fe3O4 hybrid showed significant cytotoxic effects in HepG2 cells. The results show that this novel 3D hybrid is a promising candidate for anti-cancer drug delivery systems.

Graphical abstract: The preparation and drug delivery of a graphene–carbon nanotube–Fe3O4 nanoparticle hybrid

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Supplementary files

Article information


Submitted
06 Dec 2012
Accepted
12 Mar 2013
First published
13 Mar 2013

J. Mater. Chem. B, 2013,1, 2658-2664
Article type
Paper

The preparation and drug delivery of a graphenecarbon nanotube–Fe3O4 nanoparticle hybrid

X. Fan, G. Jiao, L. Gao, P. Jin and X. Li, J. Mater. Chem. B, 2013, 1, 2658
DOI: 10.1039/C3TB00493G

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