Jump to main content
Jump to site search

Issue 9, 2014
Previous Article Next Article

Microgel film dynamics modulate cell adhesion behavior

Author affiliations


A material's mechanical properties greatly control cell behavior at the cell–substrate interface. In this work, we demonstrate that microgel multilayers have unique elastic and viscoelastic-like properties that can be modulated to produce morphological changes in fibroblasts cultured on the film. Protein adsorption is also examined and the data are contrasted with the number of cells adhered. The dynamic interaction of cell and substrate is only partially explained by conventional understanding of surface–receptor interactions and substrate elasticity. Viscoelasticity, a mechanical property not often considered, plays a significant role at cellular length and time scales for microgel films.

Graphical abstract: Microgel film dynamics modulate cell adhesion behavior

Back to tab navigation

Supplementary files

Article information

25 Sep 2013
04 Dec 2013
First published
06 Dec 2013

Soft Matter, 2014,10, 1356-1364
Article type

Microgel film dynamics modulate cell adhesion behavior

S. Saxena, M. W. Spears Jr, H. Yoshida, J. C. Gaulding, A. J. García and L. A. Lyon, Soft Matter, 2014, 10, 1356
DOI: 10.1039/C3SM52518J

Social activity

Search articles by author