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Issue 9, 2014
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Microgel film dynamics modulate cell adhesion behavior

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Abstract

A material's mechanical properties greatly control cell behavior at the cell–substrate interface. In this work, we demonstrate that microgel multilayers have unique elastic and viscoelastic-like properties that can be modulated to produce morphological changes in fibroblasts cultured on the film. Protein adsorption is also examined and the data are contrasted with the number of cells adhered. The dynamic interaction of cell and substrate is only partially explained by conventional understanding of surface–receptor interactions and substrate elasticity. Viscoelasticity, a mechanical property not often considered, plays a significant role at cellular length and time scales for microgel films.

Graphical abstract: Microgel film dynamics modulate cell adhesion behavior

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Article information


Submitted
25 Sep 2013
Accepted
04 Dec 2013
First published
06 Dec 2013

Soft Matter, 2014,10, 1356-1364
Article type
Paper

Microgel film dynamics modulate cell adhesion behavior

S. Saxena, M. W. Spears Jr, H. Yoshida, J. C. Gaulding, A. J. García and L. A. Lyon, Soft Matter, 2014, 10, 1356
DOI: 10.1039/C3SM52518J

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