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Issue 47, 2013
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Strand displacement in DNA-based materials systems

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Hybridization activity between single-stranded DNA has been well-studied for decades and employed in numerous schemes ranging from nucleic acid detection to oligonucleotide-linked nanostructures. The related, but distinct activity involving strand exchange in duplexes, however, has received less attention. The recent emergence of DNA-based technologies in which strand exchange or displacement events play key functional roles warrants a deeper understanding of how these secondary hybridization events can uniquely enable sequence recognition-based reaction cascades and reversible or reconfigurable assembly schemes in materials systems. The following review discusses the development and implementation of DNA strand exchange events for a range of nanoscale and mesoscale structures in responsive materials.

Graphical abstract: Strand displacement in DNA-based materials systems

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Article information

09 Aug 2013
24 Sep 2013
First published
25 Sep 2013

Soft Matter, 2013,9, 11160-11172
Article type
Review Article

Strand displacement in DNA-based materials systems

B. A. Baker, G. Mahmoudabadi and V. T. Milam, Soft Matter, 2013, 9, 11160
DOI: 10.1039/C3SM52157E

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