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Issue 31, 2013
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Internalization pathways of nanoparticles and their interaction with a vesicle

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Abstract

In this work we perform large scale dissipative particle dynamics (DPD) simulations to study the interaction between nanoparticles (NPs) and vesicles, and discuss their potential implications for NP–cell interactions. First, we determine the different pathways of NP internalization and their dependence on NP size, NP concentration, vesicle excess area, and NP–vesicle attraction. In particular, we identify three pathways for spontaneous NP penetration, which are here called the cooperative chain-like penetration, direct penetration and inverted micelle-like penetration, and investigate how different factors affect the penetration processes. Then, we demonstrate that adsorption of NPs often induces NP clustering on the outer and/or inner surfaces of vesicles, leading to different vesicle responses, including the change of vesicle morphology, formation of protuberance, and vesicle rupture.

Graphical abstract: Internalization pathways of nanoparticles and their interaction with a vesicle

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Supplementary files

Article information


Submitted
04 Apr 2013
Accepted
12 Jun 2013
First published
13 Jun 2013

Soft Matter, 2013,9, 7592-7600
Article type
Paper

Internalization pathways of nanoparticles and their interaction with a vesicle

X. Chen, F. Tian, X. Zhang and W. Wang, Soft Matter, 2013, 9, 7592
DOI: 10.1039/C3SM50931A

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