Jump to main content
Jump to site search
Publishing
Advanced
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 35, 2013
Previous Article Next Article

Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface†

Pat Plunkett,*a   Brian A. Camley,bc   Kimberly L. Weirich,d   Jacob Israelachvilie  and  Paul J. Atzberger*af  
Author affiliations

* Corresponding authors

a Department of Mathematics, University of California, Santa Barbara, USA
E-mail: atzberg@math.ucsb.edu

b Department of Physics, University of California, San Diego, USA

c Center for Theoretical Biological Physics, San Diego, USA

d Department of Physics, University of California, Santa Barbara, USA

e Department of Chemical Engineering, University of California, Santa Barbara, USA

f Department of Mechanical Engineering, University of California, Santa Barbara, USA

Abstract

We investigate the kinetics of supported lipid bilayer formation by the adsorption and rupture of uncharged phosphatidylcholine lipid vesicles on to a solid substrate. We model the adsorption process taking into account the distinct vesicle rupture events and growth processes. This includes (i) the initial adhesion and vesicle rupture that nucleates bilayer islands, (ii) the growth and merger of bilayer islands, (iii) enhanced adhesion of vesicles to the bilayer edge, and (iv) the final desorption of excess vesicles from the substrate. These simulation studies give insight into prior experimental observations of adsorption in which an overloading of lipid on the solid substrate occurs before formation of the final supported lipid bilayer. Our model provides an explanation for the features of the interesting universal master curve that was observed for the surface fluorescence intensity in the experimental investigations of Weirich et al.

Graphical abstract: Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

Back to tab navigation
Download options Please wait...

Supplementary files

Article information

https://doi.org/10.1039/C3SM50443C
Submitted
12 Feb 2013
Accepted
12 Jun 2013
First published
14 Jun 2013
This article is Open Access
Soft Matter, 2013,9, 8420-8427
Article type
Paper
Permissions
Request permissions

Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

P. Plunkett, B. A. Camley, K. L. Weirich, J. Israelachvili and P. J. Atzberger, Soft Matter, 2013, 9, 8420
DOI: 10.1039/C3SM50443C

This is an Open Access article. The full version of this article can be posted on a website/blog, posted on an intranet, photocopied, emailed, distributed in a course pack or distributed in CME materials provided that it is not used for commercial purposes.

If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.

Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.
  • For reproduction of material from PCCP:
    Reproduced from Ref. XX with permission from the PCCP Owner Societies.
  • For reproduction of material from PPS:
    Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.
  • For reproduction of material from all other RSC journals and books:
    Reproduced from Ref. XX with permission from The Royal Society of Chemistry.

If the material has been adapted instead of reproduced from the original RSC publication “Reproduced from” can be substituted with “Adapted from”.

In all cases the Ref. XX is the XXth reference in the list of references.

If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Reproduced by permission of the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry.

If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Social activity

Search articles by author

Spotlight

Advertisements