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Issue 35, 2013
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Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

Pat Plunkett,*a  Brian A. Camley,bc  Kimberly L. Weirich,d  Jacob Israelachvilie  and  Paul J. Atzberger*af 
Author affiliations

* Corresponding authors

a Department of Mathematics, University of California, Santa Barbara, USA
E-mail: atzberg@math.ucsb.edu

b Department of Physics, University of California, San Diego, USA

c Center for Theoretical Biological Physics, San Diego, USA

d Department of Physics, University of California, Santa Barbara, USA

e Department of Chemical Engineering, University of California, Santa Barbara, USA

f Department of Mechanical Engineering, University of California, Santa Barbara, USA

Abstract

We investigate the kinetics of supported lipid bilayer formation by the adsorption and rupture of uncharged phosphatidylcholine lipid vesicles on to a solid substrate. We model the adsorption process taking into account the distinct vesicle rupture events and growth processes. This includes (i) the initial adhesion and vesicle rupture that nucleates bilayer islands, (ii) the growth and merger of bilayer islands, (iii) enhanced adhesion of vesicles to the bilayer edge, and (iv) the final desorption of excess vesicles from the substrate. These simulation studies give insight into prior experimental observations of adsorption in which an overloading of lipid on the solid substrate occurs before formation of the final supported lipid bilayer. Our model provides an explanation for the features of the interesting universal master curve that was observed for the surface fluorescence intensity in the experimental investigations of Weirich et al.

Graphical abstract: Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

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Publication details

The article was received on 12 Feb 2013, accepted on 12 Jun 2013 and first published on 14 Jun 2013


Article type: Paper
DOI: 10.1039/C3SM50443C
Citation: Soft Matter, 2013,9, 8420-8427
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    Simulation of edge facilitated adsorption and critical concentration induced rupture of vesicles at a surface

    P. Plunkett, B. A. Camley, K. L. Weirich, J. Israelachvili and P. J. Atzberger, Soft Matter, 2013, 9, 8420
    DOI: 10.1039/C3SM50443C

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