Jump to main content
Jump to site search

Issue 12, 2013
Previous Article Next Article

Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

Author affiliations

Abstract

We describe the preparation and assembly of glycosylated amphiphilic diblock copolypeptides, where the hydrophilic glycosylated segments adopt either α-helical or disordered conformations. In this study, glycosylated amphiphilic diblock copolypeptides were prepared using poly(L-leucine), poly(L), as the hydrophobic segment, and poly(α-D-galactopyranosyl-L-lysine), poly(α-gal-K), or poly(α-D-galactopyranosyl-L-cysteine sulfone), poly(α-gal-CO2), as the hydrophilic segment. The poly(α-gal-K) and poly(α-gal-CO2) segments are known to be fully α-helical (>90% at 20 °C) and fully disordered in water, respectively. We found that block copolypeptides containing galactosylated hydrophilic segments of either α-helical or disordered conformation give different assembly morphologies, where the disordered glycopolypeptide segments favor vesicle formation and also present sugar residues that can bind to biological targets.

Graphical abstract: Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

Back to tab navigation

Supplementary files

Article information


Submitted
06 Nov 2012
Accepted
22 Jan 2013
First published
11 Feb 2013

This article is Open Access

Soft Matter, 2013,9, 3389-3395
Article type
Paper

Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

J. R. Kramer, A. R. Rodriguez, U. Choe, D. T. Kamei and T. J. Deming, Soft Matter, 2013, 9, 3389 DOI: 10.1039/C3SM27559K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements