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Issue 12, 2013
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Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

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Abstract

We describe the preparation and assembly of glycosylated amphiphilic diblock copolypeptides, where the hydrophilic glycosylated segments adopt either α-helical or disordered conformations. In this study, glycosylated amphiphilic diblock copolypeptides were prepared using poly(L-leucine), poly(L), as the hydrophobic segment, and poly(α-D-galactopyranosyl-L-lysine), poly(α-gal-K), or poly(α-D-galactopyranosyl-L-cysteine sulfone), poly(α-gal-CO2), as the hydrophilic segment. The poly(α-gal-K) and poly(α-gal-CO2) segments are known to be fully α-helical (>90% at 20 °C) and fully disordered in water, respectively. We found that block copolypeptides containing galactosylated hydrophilic segments of either α-helical or disordered conformation give different assembly morphologies, where the disordered glycopolypeptide segments favor vesicle formation and also present sugar residues that can bind to biological targets.

Graphical abstract: Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

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Publication details

The article was received on 06 Nov 2012, accepted on 22 Jan 2013 and first published on 11 Feb 2013


Article type: Paper
DOI: 10.1039/C3SM27559K
Citation: Soft Matter, 2013,9, 3389-3395
  • Open access: Creative Commons BY license
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    Glycopolypeptide conformations in bioactive block copolymer assemblies influence their nanoscale morphology

    J. R. Kramer, A. R. Rodriguez, U. Choe, D. T. Kamei and T. J. Deming, Soft Matter, 2013, 9, 3389
    DOI: 10.1039/C3SM27559K

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