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Issue 18, 2013
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Cationic poly(2-oxazoline) hydrogels for reversible DNA binding

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A new 2-oxazoline monomer with a Boc-protected amino group in the side chain (BocOx) was synthesized. Homopolymerization as well as copolymerization with 2-ethyl-2-oxazoline (EtOx) revealed a pseudo first order kinetic. A series of homopolymers was synthesized, deprotected and characterized regarding their structure and thermal properties. The copolymerization with EtOx yielded a series of water soluble polymers with varying amino contents. After deprotection it was shown by the ethidium bromide assay that these polymers were able to form complexes with DNA. Treatment with epichlorohydrin leads to the formation of hydrogels. The swelling properties of the gels were investigated and it could be demonstrated that also the polymeric scaffolds were able to immobilize DNA from aqueous solution. Furthermore, the release of the DNA was accomplished using heparin.

Graphical abstract: Cationic poly(2-oxazoline) hydrogels for reversible DNA binding

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Article information

11 Jan 2013
08 Mar 2013
First published
28 Mar 2013

Soft Matter, 2013,9, 4693-4704
Article type

Cationic poly(2-oxazoline) hydrogels for reversible DNA binding

M. Hartlieb, D. Pretzel, K. Kempe, C. Fritzsche, R. M. Paulus, M. Gottschaldt and U. S. Schubert, Soft Matter, 2013, 9, 4693
DOI: 10.1039/C3SM00114H

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