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Issue 17, 2013
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Implications of macromolecular crowding for proteinprotein association kinetics in the cytoplasm of living cells

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Abstract

We present a method of prediction of in vivo association rate constants between proteins from in vitro rate constants. This model accounts for the changes in length-scale dependent viscosity of the cytoplasm of a living cell and interaction potential between proteins. We explain the unexpected results obtained for proteinprotein association rate constants in the cytoplasm of HeLa cells determined by Phillip et al. Proc. Natl. Acad. Sci. U. S. A., 2012, 109, 1461.

Graphical abstract: Implications of macromolecular crowding for protein–protein association kinetics in the cytoplasm of living cells

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Publication details

The article was received on 02 Jan 2013, accepted on 06 Mar 2013 and first published on 26 Mar 2013


Article type: Communication
DOI: 10.1039/C3SM00013C
Soft Matter, 2013,9, 4386-4389

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    Implications of macromolecular crowding for proteinprotein association kinetics in the cytoplasm of living cells

    M. Tabaka, L. Sun, T. Kalwarczyk and R. Hołyst, Soft Matter, 2013, 9, 4386
    DOI: 10.1039/C3SM00013C

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