Jump to main content
Jump to site search

Issue 1, 2013
Previous Article Next Article

Fabrication of a shape memory hydrogel based on imidazole–zinc ion coordination for potential cell-encapsulating tubular scaffold application

Author affiliations

Abstract

A dipole–dipole reinforced copolymer hydrogel was synthesized by the one-step photopolymerization of vinylimidazole (VI) and acrylonitrile (AN) comonomer in the presence of a polyethylene glycol-based crosslinker. The mechanical properties of PVI–AN gels were tremendously increased by only chelating several mmol L−1 zinc ions, which was shown to firmly lock the temporary shape of the gel. Extraction of zinc ions by a complexing agent could facilitate the recovery of a permanent shape, and the memory behavior was reversible. The PVI–AN hydrogels supported the growth of L929 cells. The cell-seeded flat hydrogel sheet was folded into a temporary tubular scaffold and fixed in a culture medium containing 5 mmol L−1 zinc ions. After unfolding the tube, the exposed L929 cells were shown to adhere well on the surface of the gel. It is anticipated that this cell-loaded SM hydrogel could be fixed to a desired shape in vitro by small numbers of zinc ions for a potential implantable tissue engineering scaffold.

Graphical abstract: Fabrication of a shape memory hydrogel based on imidazole–zinc ion coordination for potential cell-encapsulating tubular scaffold application

Back to tab navigation

Supplementary files

Article information


Submitted
17 Aug 2012
Accepted
26 Sep 2012
First published
15 Oct 2012

Soft Matter, 2013,9, 132-137
Article type
Paper

Fabrication of a shape memory hydrogel based on imidazolezinc ion coordination for potential cell-encapsulating tubular scaffold application

W. Nan, W. Wang, H. Gao and W. Liu, Soft Matter, 2013, 9, 132
DOI: 10.1039/C2SM26918J

Social activity

Search articles by author

Spotlight

Advertisements