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Issue 3, 2013
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Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide

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Abstract

Amphiphilic star-shaped poly(ε-caprolactone)-block-poly(oligo(ethylene glycol)methacrylate) [PCLa-b-POEGMAb]4 block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

Graphical abstract: Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide

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Publication details

The article was received on 29 Jun 2012, accepted on 10 Oct 2012 and first published on 07 Nov 2012


Article type: Paper
DOI: 10.1039/C2SM26509E
Soft Matter, 2013,9, 715-726

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    Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide

    K. Knop, G. M. Pavlov, T. Rudolph, K. Martin, D. Pretzel, B. O. Jahn, D. H. Scharf, A. A. Brakhage, V. Makarov, U. Möllmann, F. H. Schacher and U. S. Schubert, Soft Matter, 2013, 9, 715
    DOI: 10.1039/C2SM26509E

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