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Issue 12, 2013
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Enantioselective [3 + 2] annulation via C–H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

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Abstract

Enantioselective [3 + 2] annulation between 1,3-dienes and N-acyl ketimines in situ generated from 3-aryl-3-hydroxyisoindolin-1-ones proceeded via C–H activation to give spiroaminoindane derivatives in high yields with high regio- and enantioselectivity, which is realized by use of an Ir/chiral diene catalyst.

Graphical abstract: Enantioselective [3 + 2] annulation via C–H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

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Publication details

The article was received on 26 Aug 2013, accepted on 20 Sep 2013 and first published on 23 Sep 2013


Article type: Edge Article
DOI: 10.1039/C3SC52379A
Chem. Sci., 2013,4, 4499-4504

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    Enantioselective [3 + 2] annulation via C–H activation between cyclic N-acyl ketimines and 1,3-dienes catalyzed by iridium/chiral diene complexes

    T. Nishimura, M. Nagamoto, Y. Ebe and T. Hayashi, Chem. Sci., 2013, 4, 4499
    DOI: 10.1039/C3SC52379A

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