Jump to main content
Jump to site search

Issue 11, 2013
Previous Article Next Article

Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

Author affiliations

Abstract

Paramagnetic probes for chemical shift imaging are described, in which a reporting tert-butyl resonance is integrated and placed about 6 to 6.5 Å from a lanthanide ion. At this distance, the resonance is shifted to a region of the 1H NMR spectral window far away from the usual 0–12 ppm range, permitting selective observation. Furthermore, judicious selection of the lanthanide ion, according to the applied magnetic field strength, leads to relaxation rate enhancements of the order of 100–200, permitting more rapid data acquisition per unit time in both spectroscopy and imaging experiments. The enhanced sensitivity allows the detection of these complexes in mice within a few minutes using shift imaging, following tail vein injection of doses of the order of 0.1 mmol kg−1.

Graphical abstract: Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 May 2013, accepted on 19 Aug 2013 and first published on 19 Aug 2013


Article type: Edge Article
DOI: 10.1039/C3SC51526E
Citation: Chem. Sci., 2013,4, 4251-4258

  •   Request permissions

    Moving the goal posts: enhancing the sensitivity of PARASHIFT proton magnetic resonance imaging and spectroscopy

    P. Harvey, A. M. Blamire, J. I. Wilson, K. N. A. Finney, A. M. Funk, P. K. Senanayake and D. Parker, Chem. Sci., 2013, 4, 4251
    DOI: 10.1039/C3SC51526E

Search articles by author

Spotlight

Advertisements