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Issue 11, 2013
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“Phosphite–urea” cooperative high-turnover catalysts for the highly selective bromocyclization of homogeranylarenes

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Abstract

Nucleophilic phosphite–urea cooperative high-turnover catalysts have been designed for the highly selective bromocyclization of homogeranylarenes. The introduction of a urea moiety and bulky aryl groups in the catalyst inhibits decomposition of the catalyst and the generation of byproducts. Only 0.5 mol% of the catalyst successfully promotes the bromocyclization of 4-homogeranyltoluene to give the desired product in 96% yield.

Graphical abstract: “Phosphite–urea” cooperative high-turnover catalysts for the highly selective bromocyclization of homogeranylarenes

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Publication details

The article was received on 22 May 2013, accepted on 01 Aug 2013 and first published on 02 Aug 2013


Article type: Edge Article
DOI: 10.1039/C3SC51432C
Chem. Sci., 2013,4, 4181-4186

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    “Phosphite–urea” cooperative high-turnover catalysts for the highly selective bromocyclization of homogeranylarenes

    Y. Sawamura, H. Nakatsuji, A. Sakakura and K. Ishihara, Chem. Sci., 2013, 4, 4181
    DOI: 10.1039/C3SC51432C

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