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Issue 11, 2013
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Intramolecular C(sp3)–H amination

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Increasing interest in C(sp3)–H bond functionalization has led to a multitude of recent advances in intramolecular C(sp3)–H amination. Direct, intramolecular C(sp3)–N bond-forming processes provide expedient access to a range of azacycles without the need for prefunctionalized amine precursors such as aminoaldehydes, aminoalkyl halides or aminoalkenes. Some of these methods have been successfully applied to the synthesis of complex natural products. This Perspective provides a historical context for these methods and describes recent contributions, as well as the remaining challenges to intramolecular C(sp3)–H amination.

Graphical abstract: Intramolecular C(sp3)–H amination

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Publication details

The article was received on 22 May 2013, accepted on 04 Jul 2013 and first published on 04 Jul 2013

Article type: Perspective
DOI: 10.1039/C3SC51420J
Chem. Sci., 2013,4, 4092-4106

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    Intramolecular C(sp3)–H amination

    J. L. Jeffrey and R. Sarpong, Chem. Sci., 2013, 4, 4092
    DOI: 10.1039/C3SC51420J

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