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Issue 8, 2013
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Responsive MR-imaging probes for N-methyl-d-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

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Abstract

A series of N-methyl-D-aspartate (NMDA) receptor-targeted MRI contrast agents has been developed, based on the known competitive NMDA antagonist, 3,4-diamino-3-cyclobutene-1,2-dione. Their use as responsive MR imaging probes has been evaluated in vitro and two contrast agents showed 170–176% enhancements in relaxation rate, following incubation with a neuronal cell line model. A derivative of the lead compound was prepared containing a biotin moiety, and both the specificity and reversibility of binding to the NMDA cell surface receptors demonstrated using confocal microscopy.

Graphical abstract: Responsive MR-imaging probes for N-methyl-d-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

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Supplementary files

Article information


Submitted
04 Apr 2013
Accepted
05 Jun 2013
First published
06 Jun 2013

Chem. Sci., 2013,4, 3148-3153
Article type
Edge Article

Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

N. Sim, S. Gottschalk, R. Pal, J. Engelmann, D. Parker and A. Mishra, Chem. Sci., 2013, 4, 3148
DOI: 10.1039/C3SC50903F

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