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Issue 6, 2013
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Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP

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Abstract

A metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP is established for the synthesis of 3-(2-oxoethyl)indolin-2-ones. This method allows 1,2-difunctionalization of the C–C double bond in N-arylacrylamides by simultaneous formation of two C(sp2)–C(sp3) bonds.

Graphical abstract: Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP

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Article information


Submitted
26 Mar 2013
Accepted
17 Apr 2013
First published
17 Apr 2013

Chem. Sci., 2013,4, 2690-2694
Article type
Edge Article

Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP

M. Zhou, R. Song, X. Ouyang, Y. Liu, W. Wei, G. Deng and J. Li, Chem. Sci., 2013, 4, 2690
DOI: 10.1039/C3SC50810B

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