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Issue 5, 2013
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Synthesis of spongistatin 2 employing a new route to the EF fragment

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Abstract

An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48–C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility issues during target assembly. These were overcome by implementing a late stage Stille cross coupling to construct the diene portion of the natural product.

Graphical abstract: Synthesis of spongistatin 2 employing a new route to the EF fragment

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Publication details

The article was received on 01 Feb 2013, accepted on 26 Feb 2013 and first published on 07 Mar 2013


Article type: Edge Article
DOI: 10.1039/C3SC50304F
Chem. Sci., 2013,4, 1989-1994
  • Open access:
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    Synthesis of spongistatin 2 employing a new route to the EF fragment

    H. Kraus, A. Français, M. O'Brien, J. Frost, A. Diéguez-Vázquez, A. Polara, N. Baricordi, R. Horan, D. Hsu, T. Tsunoda and S. V. Ley, Chem. Sci., 2013, 4, 1989
    DOI: 10.1039/C3SC50304F

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