Jump to main content
Jump to site search
Publishing
Advanced

Issue 4, 2013
Previous Article Next Article

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks†

Tarek Baati,a   Leila Njim,b   Fadoua Neffati,c   Abdelhamid Kerkeni,d   Muriel Bouttemi,a   Ruxandra Gref,e   Mohamed Fadhel Najjar,c   Abdelfateh Zakhama,b   Patrick Couvreur,e   Christian Serre*a  and  Patricia Horcajada*a  
Author affiliations

* Corresponding authors

a Institut Lavoisier UMR 8180 CNRS, Université de Versailles, Saint Quentin en Yvelines, France
E-mail: horcajada@chimie.uvsq.fr, serre@chimie.uvsq
Fax: +33(0)139254452
Tel: +33(0)139254371

b Service d'Anatomie et de Cytologie pathologiques, CHU Monastir, Tunisia

c Laboratoire de Biochimie et de Toxicologie, CHU de Monastir, Tunisia

d Unité Eléments Trace et Antioxydants, Faculté de Médecine de Monastir, Tunisia

e Faculté de Pharmacie UMR 8612 CNRS Université, Paris 11, France

Abstract

In vivo acute toxicity of high doses of nanoparticles of three different porous iron(III) carboxylate Metal–Organic Frameworks (nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.

Graphical abstract: In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

Back to tab navigation
Download options Please wait...

Supplementary files

Article information

https://doi.org/10.1039/C3SC22116D
Submitted
30 Nov 2012
Accepted
18 Jan 2013
First published
21 Jan 2013
Chem. Sci., 2013,4, 1597-1607
Article type
Edge Article
Permissions
Request permissions

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(III) metal–organic frameworks

T. Baati, L. Njim, F. Neffati, A. Kerkeni, M. Bouttemi, R. Gref, M. F. Najjar, A. Zakhama, P. Couvreur, C. Serre and P. Horcajada, Chem. Sci., 2013, 4, 1597
DOI: 10.1039/C3SC22116D

If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.

Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.
  • For reproduction of material from PCCP:
    Reproduced from Ref. XX with permission from the PCCP Owner Societies.
  • For reproduction of material from PPS:
    Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.
  • For reproduction of material from all other RSC journals and books:
    Reproduced from Ref. XX with permission from The Royal Society of Chemistry.

If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".

In all cases the Ref. XX is the XXth reference in the list of references.

If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC
  • For reproduction of material from PCCP:
    [Original citation] - Reproduced by permission of the PCCP Owner Societies
  • For reproduction of material from PPS:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
  • For reproduction of material from all other RSC journals:
    [Original citation] - Reproduced by permission of The Royal Society of Chemistry

If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Social activity

Search articles by author

Spotlight

Advertisements