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Issue 4, 2013
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In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

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Abstract

In vivo acute toxicity of high doses of nanoparticles of three different porous iron(III) carboxylate Metal–Organic Frameworks (nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.

Graphical abstract: In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks

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Supplementary files

Article information


Submitted
30 Nov 2012
Accepted
18 Jan 2013
First published
21 Jan 2013

Chem. Sci., 2013,4, 1597-1607
Article type
Edge Article

In depth analysis of the in vivo toxicity of nanoparticles of porous iron(III) metal–organic frameworks

T. Baati, L. Njim, F. Neffati, A. Kerkeni, M. Bouttemi, R. Gref, M. F. Najjar, A. Zakhama, P. Couvreur, C. Serre and P. Horcajada, Chem. Sci., 2013, 4, 1597
DOI: 10.1039/C3SC22116D

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