Issue 5, 2013

DNA-based asymmetric organometallic catalysis in water

Abstract

Here, the first examples of DNA-based organometallic catalysis in water that give rise to high enantioselectivities are described. Copper complexes of strongly intercalating ligands were found to enable the asymmetric intramolecular cyclopropanation of α-diazo-β-keto sulfones in water. Up to 84% ee was achieved, in the presence of salmon testes DNA as the only source of chirality, using dipyrido[3,2-a:2′,3′-c]phenazine (dppz) derivatives as ligands.

Graphical abstract: DNA-based asymmetric organometallic catalysis in water

Supplementary files

Article information

Article type
Edge Article
Submitted
11 Jan 2013
Accepted
15 Mar 2013
First published
15 Mar 2013

Chem. Sci., 2013,4, 2013-2017

DNA-based asymmetric organometallic catalysis in water

J. Oelerich and G. Roelfes, Chem. Sci., 2013, 4, 2013 DOI: 10.1039/C3SC00100H

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