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Issue 15, 2014
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Highly efficient one-pot multi-component synthesis of α-aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis

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Abstract

A highly efficient one-pot multi-component reaction (MCR) protocol over DTP/SiO2 has been developed for the synthesis of α-aminophosphonate derivatives (4a–x) in excellent yields. The α-aminophosphonate derivatives were for the first time evaluated for their antitubercular activity against the M. tuberculosis H37Ra (MTB) strain. An evaluation of the data on the cytotoxicity and antimicrobial activity shows that 4n and 4v are promising antitubercular agents.

Graphical abstract: Highly efficient one-pot multi-component synthesis of α-aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis

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Publication details

The article was received on 15 Oct 2013, accepted on 25 Nov 2013 and first published on 26 Nov 2013


Article type: Paper
DOI: 10.1039/C3RA45853A
RSC Adv., 2014,4, 7666-7672

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    Highly efficient one-pot multi-component synthesis of α-aminophosphonates and bis-α-aminophosphonates catalyzed by heterogeneous reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) at ambient temperature and their antitubercular evaluation against Mycobactrium Tuberculosis

    S. A. R. Mulla, M. Y. Pathan, S. S. Chavan, S. P. Gample and D. Sarkar, RSC Adv., 2014, 4, 7666
    DOI: 10.1039/C3RA45853A

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