Issue 48, 2013

Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst

Abstract

In this study, a green, simple and efficient method for the preparation of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by means of a one-pot four component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate is reported. The reaction utilizes isonicotinic acid as a dual and biological organocatalyst at 85 °C under solvent-free conditions.

Graphical abstract: Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2013
Accepted
15 Oct 2013
First published
16 Oct 2013

RSC Adv., 2013,3, 25681-25685

Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst

M. A. Zolfigol, M. Tavasoli, A. R. Moosavi-Zare, P. Moosavi, H. G. Kruger, M. Shiri and V. Khakyzadeh, RSC Adv., 2013, 3, 25681 DOI: 10.1039/C3RA45289A

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