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Issue 47, 2013
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Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

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Abstract

A new asymmetric synthesis of the antibiotic Linezolid was performed through a copper-catalyzed Henry reaction as the key step. The use of camphor-derived aminopyridine ligands helped to improve the yields of the chiral precursor and to obtain Linezolid in good overall yield and enantiomeric excess.

Graphical abstract: Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

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Publication details

The article was received on 17 Sep 2013, accepted on 18 Oct 2013 and first published on 21 Oct 2013


Article type: Paper
DOI: 10.1039/C3RA45186K
RSC Adv., 2013,3, 24946-24951

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    Concise asymmetric synthesis of Linezolid through catalyzed Henry reaction

    A. P. Piccionello, P. Pierro, A. Accardo, S. Buscemi and A. Pace, RSC Adv., 2013, 3, 24946
    DOI: 10.1039/C3RA45186K

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