Issue 44, 2013
From the journal:

RSC Advances

Bismuth triflate-catalyzed condensation of indoles with acetone†

Ganesh M. Shelke,a   V. Kameshwara Rao,a   Rakesh K. Tiwari,b   Bhupender S. Chhikara,b   Keykavous Parangb  and  Anil Kumar*a  

* Corresponding authors

a Department of Chemistry, Birla Institute of Technology and Science, Pilani, Pilani 333031, India
E-mail: anilkumar@pilani.bits-pilani.ac.in
Fax: +91 1596 244183
Tel: +91 1596 515514

b Department of Biomedical & Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, UK

Abstract

Reaction of different substituted indoles with acetone was investigated using Bi(OTf)3 as a catalyst. An efficient protocol was developed for the synthesis of spiro indoles, 1-methyl-cyclopenta[b]indole and bis(1-methyl-1H-indolyl)propanes via the reaction of indole with acetone in the presence of Bi(OTf)3. The reaction conditions were benign, required shorter reaction time, and gave good yields.

Graphical abstract: Bismuth triflate-catalyzed condensation of indoles with acetone

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Article information

DOI
https://doi.org/10.1039/C3RA44693J
Article type
Paper
Submitted
27 Aug 2013
Accepted
12 Sep 2013
First published
13 Sep 2013

RSC Adv., 2013,3, 22346-22352

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Bismuth triflate-catalyzed condensation of indoles with acetone

G. M. Shelke, V. K. Rao, R. K. Tiwari, B. S. Chhikara, K. Parang and A. Kumar, RSC Adv., 2013, 3, 22346 DOI: 10.1039/C3RA44693J

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