Microwave-assisted copper-catalyzed hydroxylation of aryl halides in water†
Abstract
A simple and efficient protocol for microwave-assisted copper-catalyzed hydroxylation of aryl halides is developed. A variety of phenols can be obtained in moderate to excellent yields of up to 95%. Its application is performed to synthesize 2,3-dihydroxy-1,4-naphthoquinone, which displays significant anti-proliferation effect.