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Issue 43, 2013
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A novel and efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes over a heterogeneous, reusable silica-supported dodecatungstophosphoric acid catalyst

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Abstract

A novel and efficient protocol has been developed for the synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes with isatin in good to excellent yield. This is the first example in which heterogeneous, reusable silica supported dodecatungstophosphoric acid (DTP/SiO2) catalyzed sp3 C–H functionalization of 2-substituted azaarenes and (2-azaaryl)methanes.

Graphical abstract: A novel and efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes over a heterogeneous, reusable silica-supported dodecatungstophosphoric acid catalyst

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The article was received on 10 Jul 2013, accepted on 16 Aug 2013 and first published on 19 Aug 2013


Article type: Paper
DOI: 10.1039/C3RA43515F
RSC Adv., 2013,3, 20281-20286

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    A novel and efficient synthesis of azaarene-substituted 3-hydroxy-2-oxindoles via sp3 C–H functionalization of 2-methyl azaarenes and (2-azaaryl)methanes over a heterogeneous, reusable silica-supported dodecatungstophosphoric acid catalyst

    S. A. R. Mulla, M. Y. Pathan and S. S. Chavan, RSC Adv., 2013, 3, 20281
    DOI: 10.1039/C3RA43515F

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