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Issue 40, 2013

Multi-parametric reference nanomaterials for toxicology: state of the art, future challenges and potential candidates

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Abstract

A major requirement for the validation of methods assessing the risk associated with engineered nanoparticles (ENPs) is the use of reference materials (RMs). In the present contribution we review available RMs, ongoing projects and characterisation trends in the field. The conclusion is that actual approaches to RMs mostly deal with metrological considerations about single properties of the ENPs, typically their primary size, which can hardly be representative of nanoparticles characteristics in real testing media and therefore, not valid for reliable and comparable toxicological studies. As an alternative, we discussed the convenience and feasibility of establishing multi-parametric RMs for a series of ENPs, focusing on silica nanoparticles (SNPs). As a future perspective, the need to develop RMs based on hybrid nanoparticles is also discussed.

Graphical abstract: Multi-parametric reference nanomaterials for toxicology: state of the art, future challenges and potential candidates

Article information


Submitted
29 Apr 2013
Accepted
04 Jul 2013
First published
08 Jul 2013

This article is Open Access

RSC Adv., 2013,3, 18202-18215
Article type
Review Article

Multi-parametric reference nanomaterials for toxicology: state of the art, future challenges and potential candidates

G. Orts-Gil, K. Natte and W. Österle, RSC Adv., 2013, 3, 18202 DOI: 10.1039/C3RA42112K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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