Issue 21, 2013
From the journal:

RSC Advances

Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)†

Dinneswara Reddy Guda,a   Hyeon Mo Choa  and  Myong Euy Lee*a  

* Corresponding authors

a Department of Chemistry & Medical Chemistry, College of Science and Technology, Research & Education Center for Advanced Silicon Materials, Yonsei University, Wonju, Gangwon-do 220-710, South Korea
E-mail: melgg@yonsei.ac.kr
Fax: + 82-33-760-2182
Tel: + 82-33-760-2237

Abstract

A mild, convenient, and efficient one-pot synthesis of amino-1,3,4-oxadiazoles is described. In situ preparation of various thiosemicarbazides by the reaction of different carboxylic acid hydrazides with trimethylsilyl isothiocyanate (TMSNCS), followed by cyclodesulfurization of thiosemicarbazides under basic conditions in the presence of I2/KI resulted in 2-amino-1,3,4-oxadiazoles in high yields (79–94%).

Graphical abstract: Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

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Article information

DOI
https://doi.org/10.1039/C3RA41044G
Article type
Communication
Submitted
02 Mar 2013
Accepted
14 Mar 2013
First published
20 Mar 2013

RSC Adv., 2013,3, 7684-7687

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Mild and convenient one-pot synthesis of 2-amino-1,3,4-oxadiazoles promoted by trimethylsilyl isothiocyanate (TMSNCS)

D. R. Guda, H. M. Cho and M. E. Lee, RSC Adv., 2013, 3, 7684 DOI: 10.1039/C3RA41044G

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