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Issue 27, 2013
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Double-headed nucleotides in DNA-zipper structures; base–base interactions and UV-induced cross-coupling in the minor groove

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Abstract

Nucleic acids containing double-headed nucleotides with additional nucleobases attached to the 5′(S)-position of thymidine through a methylene linker are studied. The additional bases are oriented towards base-base interactions in the minor groove of the DNA-double helix. Two new examples with adenine or cytosine as the additional bases as well as an analogue with a 4N-methylpiperazine in the same position are introduced, and in a combined study with the original double-headed nucleotide containing two thymines, interactions between the additional nucleobases across the minor groove are detected. Finally, a duplex with two thymines in the minor groove is cross-linked using UV irradiation.

Graphical abstract: Double-headed nucleotides in DNA-zipper structures; base–base interactions and UV-induced cross-coupling in the minor groove

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Publication details

The article was received on 20 Feb 2013, accepted on 04 Apr 2013 and first published on 04 Apr 2013


Article type: Paper
DOI: 10.1039/C3RA40857D
RSC Adv., 2013,3, 10696-10706
  • Open access: Creative Commons BY license
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    Double-headed nucleotides in DNA-zipper structures; base–base interactions and UV-induced cross-coupling in the minor groove

    C. S. Madsen, L. J. Nielsen, N. S. Pedersen, A. Lauritsen and P. Nielsen, RSC Adv., 2013, 3, 10696
    DOI: 10.1039/C3RA40857D

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