Issue 27, 2013

Photothermally enhanced drug release by κ-carrageenan hydrogels reinforced with multi-walled carbon nanotubes

Abstract

Temperature and near infrared (NIR) light responsive multi-walled carbon nanotube (MWCNT)–κ-carrageenan hydrogel composites have been prepared. The effects of the MWCNTs on the microstructure, strength, swelling and release properties of the resultant materials were investigated. MWCNTs acted as reinforcing fillers and enhanced the mechanical properties of the hydrogels, the effect being mostly nanotube concentration dependent. Surface functionalization of nanotubes had a major influence on the swelling of the composites. The increased release of a model drug (methylene blue) in in vitro conditions, from κ-carrageenan hydrogel composites due to the NIR photothermal effect of MWCNTs was demonstrated at the physiological temperature. Thus, these composites are promising materials for the development of carriers for remotely activated drug delivery.

Graphical abstract: Photothermally enhanced drug release by κ-carrageenan hydrogels reinforced with multi-walled carbon nanotubes

Supplementary files

Article information

Article type
Paper
Submitted
06 Feb 2013
Accepted
09 May 2013
First published
10 May 2013

RSC Adv., 2013,3, 10828-10836

Photothermally enhanced drug release by κ-carrageenan hydrogels reinforced with multi-walled carbon nanotubes

A. C. Estrada, A. L. Daniel-da-Silva and T. Trindade, RSC Adv., 2013, 3, 10828 DOI: 10.1039/C3RA40662H

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