Issue 18, 2013
From the journal:

RSC Advances

A simple and novel method for the direct conversion of carboxylic acids into thioamides†

Babak Kaboudin,*a   Vahid Yarahmadi,a   Jun-ya Katob  and  Tsutomu Yokomatsub  

* Corresponding authors

a Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava zang, Zanjan, Iran
E-mail: kaboudin@iasbs.ac.ir
Fax: +98 241 4214949
Tel: +98 241 4153220

b School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

We report here a simple, efficient, practical and direct method for the conversion of carboxylic acids into thioamides. As described below, the reaction of a variety of aromatic and aliphatic carboxylic acids in the presence of ammonium phosphorodithioates proceeded effectively to afford the corresponding thioamides in good yields. This thioamidation reaction is operationally straightforward and provides primary, secondary and tertiary thioamides from corresponding carboxylic acids.

Graphical abstract: A simple and novel method for the direct conversion of carboxylic acids into thioamides

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Article information

DOI
https://doi.org/10.1039/C3RA23414B
Article type
Paper
Submitted
19 Dec 2012
Accepted
18 Feb 2013
First published
19 Feb 2013

RSC Adv., 2013,3, 6435-6441

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A simple and novel method for the direct conversion of carboxylic acids into thioamides

B. Kaboudin, V. Yarahmadi, J. Kato and T. Yokomatsu, RSC Adv., 2013, 3, 6435 DOI: 10.1039/C3RA23414B

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