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Issue 16, 2013
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Blood triggered rapid release porous nanocapsules

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Abstract

Rapid-release drug delivery systems present a new paradigm in emergency care treatments. Such systems combine a long shelf life with the ability to provide a significant dose of the drug to the bloodstream in the shortest period of time. Until now, development of delivery formulations has concentrated on slow release systems to ensure a steady concentration of the drug. To address the need for a quick release system, we created hollow polyacrylate nanocapsules with nanometer-thin porous walls. Burst release occurs upon interaction with blood components that leads to escape of the cargo. The likely mechanism of release involves a conformational change of the polymer shell caused by binding albumin. To demonstrate this concept, a near-infrared fluorescent dye indocyanine green (ICG) was incorporated inside the nanocapsules (NCs). ICG-loaded nanocapsules demonstrated a remarkable shelf life in aqueous buffers with no release of ICG for twelve months. Rapid release of the dye was demonstrated first in vitro using albumin solution and serum. SEM and light scattering analysis demonstrated the retention of the nanocapsule architecture after the release of the dye upon contact with albumin. In vivo studies using fluorescence lifetime imaging confirmed quick discharge of ICG from the nanocapsules following intravenous injection.

Graphical abstract: Blood triggered rapid release porous nanocapsules

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Publication details

The article was received on 30 Oct 2012, accepted on 23 Jan 2013 and first published on 24 Jan 2013


Article type: Paper
DOI: 10.1039/C3RA22693J
RSC Adv., 2013,3, 5547-5555

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    Blood triggered rapid release porous nanocapsules

    T. P. Gustafson, S. A. Dergunov, W. J. Akers, Q. Cao, S. Magalotti, S. Achilefu, E. Pinkhassik and M. Y. Berezin, RSC Adv., 2013, 3, 5547
    DOI: 10.1039/C3RA22693J

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