Issue 14, 2013
From the journal:

RSC Advances

Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery†‡

Mohammad Saquib,a   Irfan Husain,a   Ruchir Kant,b   Sanjeev Meena,c   H. M. Gauniyal,d   Sudhir Sinha,c   P. R. Maulikb  and  Arun K. Shaw*a  

* Corresponding authors

a Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, India
E-mail: akshaw55@yahoo.com
Tel: +91-9415403775

b Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, India

c Drug Target Discovery and Development Division, CSIR-Central Drug Research Institute, Lucknow, India

d Sophisticated Analytical Instruments Facility, CSIR-Central Drug Research Institute, Lucknow, India

Abstract

A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar–pyrazole hybrid molecules with multiple sites for structural diversification and a non-flat skeleton as potential drug scaffolds is reported. Four representative hybrid molecules were screened for in vitro anti-cancer activity, wherein three of them were found to exhibit good anti-cancer activity.

Graphical abstract: Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery

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Article information

DOI
https://doi.org/10.1039/C3RA22287J
Article type
Communication
Submitted
25 Sep 2012
Accepted
01 Feb 2013
First published
05 Feb 2013

RSC Adv., 2013,3, 4526-4530

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Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery

M. Saquib, I. Husain, R. Kant, S. Meena, H. M. Gauniyal, S. Sinha, P. R. Maulik and A. K. Shaw, RSC Adv., 2013, 3, 4526 DOI: 10.1039/C3RA22287J

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