Issue 14, 2013
From the journal:

RSC Advances

Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents†

Atul Kumar,*a   Garima Gupta,a   Suman Srivastava,a   Ajay Kumar Bishnoi,a   Ruchi Saxena,b   Ruchir Kant,c   Ranjana S. Khanna,d   Prakas R. Maulikc  and  Anila Dwivedib  

* Corresponding authors

a Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow-226001, India
E-mail: dratulsax@gmail.com
Fax: 91-522-2623405
Tel: 91-522-2612411

b Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow-226001, India

c Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow-226001, India

d Department of Chemistry, Banaras Hindu University, Varanasi-221005, U.P., India

Abstract

A novel class of diastereoselective spiropyrrolidine-oxindole derivatives were synthesized from isatin, 2-phenylthiazolidine-4-carboxylic acid and chalcone in a one-pot multicomponent reaction via 1,3-dipolar cycloaddition. The advantages of this methodology are the mild reaction conditions, high diastereoselectivity and high yield. These derivatives exhibited promising anti-cancer activity against the human breast cancer cell lines.

Graphical abstract: Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

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Article information

DOI
https://doi.org/10.1039/C3RA21595D
Article type
Paper
Submitted
27 Jul 2012
Accepted
05 Dec 2012
First published
25 Jan 2013

RSC Adv., 2013,3, 4731-4735

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Novel diastereoselective synthesis of spiropyrrolidine-oxindole derivatives as anti-breast cancer agents

A. Kumar, G. Gupta, S. Srivastava, A. K. Bishnoi, R. Saxena, R. Kant, R. S. Khanna, P. R. Maulik and A. Dwivedi, RSC Adv., 2013, 3, 4731 DOI: 10.1039/C3RA21595D

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