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Issue 10, 2013
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Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

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Abstract

3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase is an important biosynthetic enzyme in Mycobacterium tuberculosis and a potential drug target. We describe the synthesis, evaluation and docking of inhibitors with various chain lengths, which provide insight into the plasticity of the active site for inhibitor binding.

Graphical abstract: Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

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Publication details

The article was received on 26 Oct 2012, accepted on 14 Jan 2013 and first published on 16 Jan 2013


Article type: Communication
DOI: 10.1039/C3RA00037K
Citation: RSC Adv., 2013,3, 3209-3212
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    Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

    S. Reichau and E. J. Parker, RSC Adv., 2013, 3, 3209
    DOI: 10.1039/C3RA00037K

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