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Issue 10, 2013
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Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

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Abstract

3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase is an important biosynthetic enzyme in Mycobacterium tuberculosis and a potential drug target. We describe the synthesis, evaluation and docking of inhibitors with various chain lengths, which provide insight into the plasticity of the active site for inhibitor binding.

Graphical abstract: Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

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Article information


Submitted
26 Oct 2012
Accepted
14 Jan 2013
First published
16 Jan 2013

RSC Adv., 2013,3, 3209-3212
Article type
Communication

Active site plasticity of a critical enzyme from Mycobacterium tuberculosis

S. Reichau and E. J. Parker, RSC Adv., 2013, 3, 3209
DOI: 10.1039/C3RA00037K

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