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Issue 22, 2013
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Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: facile construction of pharmaceutically analogous bis-alkaloid scaffolds

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Abstract

An efficient sodium hydrogen sulfate catalyzed alkylation of indoles or amines with tertiary enamides has been accomplished in water, affording the pharmacologically and biologically active 2-oxo-1-pyrrolidine derivatives in moderate to excellent yields. The key to our success is the use of NaHSO4 as a low loading, inexpensive, green and recyclable catalyst and the reactions could be scaled up to gram level.

Graphical abstract: Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: facile construction of pharmaceutically analogous bis-alkaloid scaffolds

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Publication details

The article was received on 19 Feb 2013, accepted on 19 Mar 2013 and first published on 20 Mar 2013


Article type: Paper
DOI: 10.1039/C3RA40833G
RSC Adv., 2013,3, 8380-8387

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    Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: facile construction of pharmaceutically analogous bis-alkaloid scaffolds

    X. Chu, S. Wang and S. Ji, RSC Adv., 2013, 3, 8380
    DOI: 10.1039/C3RA40833G

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