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A bifunctional monomer FGG-PEG8-GGF bearing two Phe-Gly-Gly residues and an octaethylene glycol linker has been designed and synthesized. Water-soluble supramolecular polymers can form spontaneously by mixing the monomer and cucurbit[8]uril (CB[8]) in a 1 : 1 ratio through specific interactions between CB[8] and the Phe-Gly-Gly residues.

Graphical abstract: Water-soluble supramolecular polymers fabricated through specific interactions between cucurbit[8]uril and a tripeptide of Phe-Gly-Gly

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