Issue 19, 2013
From the journal:

Polymer Chemistry

Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery†

Haijun Yu,a   Zhiai Xu,b   Dangge Wang,a   Xianzhi Chen,a   Zhiwen Zhang,a   Qi Yina  and  Yaping Li*a  

* Corresponding authors

a Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: ypli@simm.ac.cn
Fax: +86-21-2023-1979
Tel: +86-21-2023-1979

b Department of Chemistry, East China Normal University, Shanghai 200241, P.R. China

Abstract

Wormlike micelles with intracellular pH-activating properties were developed. The micelles remained in a “silent” state at physiological pH conditions (i.e. pH 7.4), but were activated in the acidic microenvironment of endocytic vesicles. The wormlike micelles could be employed as nanovectors for the intracellular delivery of hydrophobic drugs for cancer therapy.

Graphical abstract: Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

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Article information

DOI
https://doi.org/10.1039/C3PY00849E
Article type
Communication
Submitted
01 Jul 2013
Accepted
15 Jul 2013
First published
16 Jul 2013

Polym. Chem., 2013,4, 5052-5055

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Intracellular pH-activated PEG-b-PDPA wormlike micelles for hydrophobic drug delivery

H. Yu, Z. Xu, D. Wang, X. Chen, Z. Zhang, Q. Yin and Y. Li, Polym. Chem., 2013, 4, 5052 DOI: 10.1039/C3PY00849E

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