Issue 11, 2013
From the journal:

Polymer Chemistry

A controlled and versatile NCA polymerization method for the synthesis of polypeptides†‡

Inmaculada Conejos-Sánchez,§a   Aroa Duro-Castano,§a   Alexander Birke,b   Matthias Barz*b  and  María J. Vicent*a  

* Corresponding authors

a Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab., Avda Eduardo Primo Yúfera 3, 46012 Valencia, Spain
E-mail: mjvicent@cipf.es
Fax: +34 963289701
Tel: +34 963289680

b Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany
E-mail: barz@uni-mainz.de
Fax: +49 6131 39 24778
Tel: +49 6131 39 26256

Abstract

A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of α-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.

Graphical abstract: A controlled and versatile NCA polymerization method for the synthesis of polypeptides

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Article information

DOI
https://doi.org/10.1039/C3PY00347G
Article type
Communication
Submitted
14 Mar 2013
Accepted
06 Apr 2013
First published
08 Apr 2013

Polym. Chem., 2013,4, 3182-3186

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A controlled and versatile NCA polymerization method for the synthesis of polypeptides

I. Conejos-Sánchez, A. Duro-Castano, A. Birke, M. Barz and M. J. Vicent, Polym. Chem., 2013, 4, 3182 DOI: 10.1039/C3PY00347G

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